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. 2021 Dec 21;11:24334. doi: 10.1038/s41598-021-03694-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mice used and general appearance of Cx30 and Cx43 in perivascular astrocyte domains. (a) Diagrams of gap junction composition of transgenic mice used in this study arranged in order of decreasing Cx43 expression. Mice used were: Cx43 WT but Cx30 null [Cx43^(+/+)/Cx30^(−/−)], Cx43 heterozygous [Cx43^(+/−)/Cx30^(+/+)], heterozygous for the M258 truncation [Cx43^(Δ/−)/Cx30^(+/+)], and dKO [hGFAP-Cre:Cx43^(fl/fl)/Cx30^(−/−)]. (b, c) Double immunolabeling with CD31 to localize endothelial cells in brain vessels and with antibody for either Cx43 (b) or Cx30 (c) in each of the genotypes illustrated in (a). Note localization of both Cx30 and Cx43 nearby CD31, indicating that both connexins are present at astrocyte endfeet. Arrowheads indicate the vessels. Scale bar: 50 µm.