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. 2021 Dec 21;11:24334. doi: 10.1038/s41598-021-03694-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ratio of AQP4ex/AQP4 density and size in perivascular brain regions of the Cx43 genotypes. (a) Ratios of particle densities of AQP4ex to AQP4 shows that dKO has higher ratio than the other genotypes. (b) Ratios of particle sizes shows that Cx43^(+/+) and Cx43^(+/−) are similar but the size of AQP4 is smaller than AQP4ex for the other groups. Data are presented as mean ± SEM (ANOVA followed by Tukey’s post hoc test: *p < 0.05 and **p < 0.01).