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. 2021 Dec 21;11:24336. doi: 10.1038/s41598-021-03731-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of differential expression of full-length ACE2 and the short dACE2 isoform in specific structures of human tissues. Graphical output shows the fold change in mean fluorescence observed for the respective secondary antibodies used to visualise ACE2poly and ACE2mono in distinct anatomical structures of the human tissue sections shown in Fig. 3. For each structure, n = 6 from ≥ 2 tissue sections. (a) Fold change in mean fluorescence observed for ACE2poly and ACE2mono in kidney cortex and glomeruli (Glom.), versus the normalised mean fluorescence observed in the renal medulla. (b) Fold change in mean fluorescence observed for ACE2poly and ACE2mono in airway structures and blood vessels (Blood ves.) of the lung, versus the normalised mean fluorescence observed in the connective tissue (Connec.). (c) Fold change in mean fluorescence observed for ACE2poly and ACE2mono in liver bile ducts and blood vessels (Blood ves.), versus the normalised mean fluorescence observed in liver hepatocytes (Hepato.). All data show mean ± SEM with individual data points shown. Statistical analyses of data included a one way ANOVA with multiple comparisons using Tukey’s correction. Statistical significance was determined where p < 0.05. **** or ^#### = p < 0.0001; ** = p < 0.01; n.s. = no significant difference.