Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 8;15:747951. doi: 10.3389/fnins.2021.747951

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Nakagawa-Tamagawa, Kirino, Sugao, Nagata and Tagawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Expression of the Cav1.2 I1166T mutant caused neuronal migration deficit. (A) Left, GFP images of electroporated cortex in the GFP-alone group. Cyan lines represent the top; pial surface, the bottom edge of the GFP-positive neuron cluster, and the top and bottom edge of white matter (see section “Materials and Methods”). Right, histogram of radial index (RI) of the GFP-positive neurons. Colors, each sample. Black, mean ± SEM. Y-axis is enlarged and shown at the bottom. (B,C) Images and histograms of the Cav1.2^WT group (B) and Cav1.2^I1166T group (C), as shown in (A). (D) Histogram of the mean ± SEM are merged for GFP-alone, Cav1.2^WT, and Cav1.2^I1166T groups. (E) Proportion of correctly migrated neurons (top) and migration-failed neurons in WM and Middle (bottom). Independent values and mean ± SEM are shown. ***P < 0.001; *P < 0.05; n.s., P ≥ 0.05.