Table 2.

Summary of antiviral-target and antiviral-HPV protein interaction dataset used in machine learning processing of this study.

Dataset	Antiviral drug	Target protein	Antiviral-protein interaction pair
Training set	35	34	102c
Validation seta	61	47	182c,d
Prediction set	96	9b	864

^aValidation set consisted of U.S.FDA-approved antiviral drugs and these drugs’ binding target proteins.

^b9 proteins of HPV-16.

^cRatio of positive instance to negative instance was 1:1.

^dNumber of validation set was greater than that of training set because (1) more FDA-approved antivirals were desired for validating the real-world application value of our machine learning models; (2) generalization performance of machine learning models could be reflected using smaller training set but larger validation set.