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. 2021 Dec 21;11:24357. doi: 10.1038/s41598-021-03662-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Volcano plots displaying distinct m6A-modified circRNAs and their statistical significance (fold change ≥ 5 and P < 0.05) (a). The main consensus motif (GAGGC) was identified in both the control and PE groups by sensitive, thorough, rapid enriched motif elicitation (STREME) of m6A sequencing data (b). m6A peaks were enriched in the CDS or 3′UTR of the PAPPA gene according to alignment visualization. The squares mark increases in m6A peaks in PE compared with control samples (IGV software, genome: Homo_sapiens_HG19) (c) (IP: m6A RNA immunoprecipitation).