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. 2021 Dec 21;11:24357. doi: 10.1038/s41598-021-03662-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Through overexpression experiments, insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) was found to increase circPAPPA2 expression but have no effect on the levels of m6A on circPAPPA2 (a). RNA immunoprecipitation (RIP) revealed that IGF2BP3 can bind to circPAPPA2 (b). Luciferase assay results showed that downregulation of IGF2BP3 can downregulate circPAPPA2 expression in an m6A-dependent manner (c). In an analysis of circPAPPA2 stability, after transcriptional inhibition using actinomycin D, overexpression of IGF2BP3 increased the circPAPPA2 half-life (d); knockdown of IGF2BP3 in TEV1 cells shortened the circPAPPA2 half-life (e) (all *P < 0.05).