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. 2021 Dec 21;13(1):25. doi: 10.1038/s41419-021-04470-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A heat map showing miRs with significant accumulation (fold change > 2, p < 0.05) in colonic crypts from Apc^min mice (12 weeks old) administered (rectal instillation) with the Meg3-overexpressing adenovirus (Adv-Meg3) or control adenovirus (Adv-ctrl). b The relative expression of miR-708 in 20 pairs of CRC samples and adjacent normal samples by qPCR analyses. c The relative expression of miR-708 in tissues with different disease stages of CRC from TCGA dataset. d RNA-FISH assay was performed to detect the level and location of miR-708 in colonic adenoma from Apc^min mouse (22 weeks old). e, f The relative expression of miR-708 in colonic tissues (e) and plasma (f) from Apc^min mice of the indicated ages. g–i Plots showing the correlation between miR-708 and Meg3 levels in human CRC tissues (g), Apc^min mouse colonic tissues (h), and CRC cell lines (i). The results are presented as the mean ± S.D. in panels (b, c, e, f). **p < 0.01, ***p < 0.001 (non-paired two-tailed Student’s t test).