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. 2021 Dec 21;13(1):25. doi: 10.1038/s41419-021-04470-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–c Apc^min WT mice or Apc^min KO mice were infected with Adv-Meg3, Adv-SOCS3i, or Adv-Meg3 + Adv-SOCS3i by coloclysis. a Representative images of colonic tumors from Apc^min mice subjected to the indicated treatments. b Plot showing the numbers of tumors (diameter: 2–4 mm) from Apc^min mice subjected to the indicated treatments. c The statistics of the diameters of tumors from Apc^min mice subjected to the indicated treatments. d Typical images (scale bar: 100 μm) of organoids derived from the mice presented in (a). e, f Plots showing the correlation between miR-708, Meg3, and SOCS3 levels in CRC tissues (N = 22). The results are presented as the mean ± S.D. in panels (b and c). NS not significant (non-paired two-tailed Student’s t test).