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. 2022 Jan 1;13(1):62–75. doi: 10.7150/jca.66016

Figure 5.

Figure 5

miR-449a-5p and knockdown of PEA15, PPP1CA and TUFT1 reduce endothelial cell tube formation. (A) Representative images of capillary-like tubular structures of human umbilical vein endothelial cells (HUVEC) on Matrigel when co-cultured with miR-449a-5p/miR-control or siRNA/si-control transfected HLE or Huh7 cells. Angiogenic changes were imaged using an inverted light microscope. Scale bar = 200.00 µm (B) Angiogenic parameters (number of tubes, segment length, number of junctions and number of nodes) were quantified with Angiogenesis Analyzer from ImageJ. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001; two-way ANOVA with Sidak's multiple comparisons test.