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PAK3 up-regulation is tightly associated with HCC malignancy and poor survival of patients. (a) The GSE138485 data confirmed that PAK family members are highly expressed in HCC. (b) Relative expression of PAK3 in 50 HCC patients quantified by quantitative real-time PCR and compared with the adjacent normal samples. (c and d) Patients with HCC were stratified by the PAK3 level, OS and DFS were assessed by Kaplan-Meier analysis.*P < 0.05; **P < 0.01; ****P<0.0001.
