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. 2022 Jan 1;13(1):162–173. doi: 10.7150/jca.64082

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The relationship between CXCL12 mRNA expression and procancer pathways in locally advanced rectal cancer (LARC) (A) CXCL12 mRNA expression levels are significant prognostic factors for overall survival in GSE133057 (n=33, p = 0.047; log-rank test). (B) Correlation of CXCL12 expression with immune cell infiltration level in LARC. (C) Gene set enrichment analysis (GSEA) reveals correlation between CXCL12 expression and genes involved in epithelial-mesenchymal transition and angiogenesis. GSEA probing for enrichment of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION and HALLMARK_ANGIOGENESIS (READ, rectal adenocarcinoma).