Table 3.

Effect of Anemia on OS in entire and matched cohorts: results of Cox proportional hazard model.

Variables	Before propensity matching				After propensity matching
	Crude model		Adjusted model		Crude model		Adjusted model
	HR(95%CI)	P-value	HR(95%CI)	P-value	HR(95%CI)	P-value	HR(95%CI)	P-value
No anemia	1		1		1		1
Anemia	1.3(1.1,1.6)	0.008	1.4(1.1,1.7)	0.013	1.7(1.3, 2.3)	<0.001	1.6(1.1,2.2)	0.003
Hb(per 1g/dl decrease)	1.1(1.0,1.1)	<0.001	1.1(1.1,1.2)	<0.001	1.1(1.0, 1.2)	0.001	1.1(1.0,1.2)	0.018

Crude mode adjusted for: None.

Adjusted model adjusted for: Age; Sex; Smoking history; ECOG PS; BMI; Pathology; Differentiation; ALK fusion; EGFR mutation; Sum of metastasis organs; Treat type of 1st line therapy; Sum of treatment lines

*p values<0.05 were considered statistically significant.