Table 1.

Overview of BAP1 Mutations Detected in 20 HCC samples

Sample	Somatic	Protein change	Mutation type	copy	Cosmic occurrence	Allele frequency
1	Yes	G45R	Missense	Diploid	1	0.26
	Yes	K711*	Nonsense	Diploid	1	0.23
2	Yes	M115Rfs*9	FS del	Shallow deletion		0.43
3	Yes	X146_splice	Splice	Shallow deletion		0.62
4	Yes	Q156*	Nonsense	Diploid	1	0.37
	Yes	Q456*	Nonsense	Diploid		0.46
5	Yes	H169Q	Missense	Shallow deletion	5	0.59
6	Yes	F170V	Missense	Diploid	4	0.14
7	Yes	W196G	Missense	Shallow deletion	1	0.57
8	Yes	W202L	Missense	Shallow deletion		0.64
9	Yes	P235_R237del	IF del	Shallow deletion		0.82
10	Yes	Q253*	Nonsense	Shallow deletion	2	0.58
11	Yes	L259Rfs*2	FS del	Deep deletion		0.46
12	Yes	Q280*	Nonsense	Shallow deletion	1	0.64
13	Yes	A359Tfs*68	FS del	Shallow deletion		0.31
14	Yes	K421Rfs*9	FS del	Shallow deletion	1	0.35
15	Yes	K453Rfs*15	FS del	Diploid	2	0.32
16	Yes	L539Q	Missense	Diploid		0.16
17	Yes	V569Cfs*2	FS del	Shallow deletion		0.35
18	Yes	X662_splice	Splice	Shallow deletion		0.30
19	Yes	D663*	FS ins	Shallow deletion		0.45
20	Yes	I679Yfs*38	FS ins	Shallow deletion		0.34