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. 2022 Jan 1;13(1):184–201. doi: 10.7150/jca.65225

Figure 3.

Figure 3

Alteration analyzed of SNRPD1 and identification of co-expressed genes and construction of protein-protein interaction (PPI) network. (A) The mutation spectrum, alteration and expression heatmap of SNRPD1 in a cohort of 349 HCC patients in the cBioPortal database. 7% cases of this cohort exhibited alteration, including 2 cases of amplification, and 23 cases of mRNA high expression. (B-C) The overall survival (B), and the disease-free survival (C) of HCC patients with SNRPD1 alterations (n=25), was poorer than without SNRPD1 alterations (n=324). (D-F) SNRPD1 expression associated target genes analysis in the LinkedOmics database. (D) Volcano chart exhibited SNRPD1 expression positively/negatively correlated significant genes. (E) The top 50 genes that are positively associated with SNRPD1 expression. (F) The top 50 genes that are negatively associated with SNRPD1 expression. (G)81 overlapping correlated genes with Spearman's Correlation greater than 0.6 were screened as SNRPD1 co-expressed genes. (H) PPI network for 81 co-expressed genes of SNRPD1 was constructed and visualized. SNRPA, SNRPB, SNRPB2, SNRPD2, SNRPE, SNRPG, POLR2H, and PRMT1 protein can interact with SNRPD1.