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. 2021 Dec 8;12:789487. doi: 10.3389/fneur.2021.789487

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Copyright © 2021 Nguyen, Nam, Kang, Han, Kim, Dieterich and Oh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the locomotor activities of mice using an open-field task. The open field apparatus with an overhead camera and lighting support system (A). The recorded images were processed with the digital video-based tracking system (B). The total path lengths of the Lt.- unilateral labyrinthectomy (UL) and Rt.-UL groups were decreased in comparison to the control group on postoperative days (PODs) 3, 7, and 14. On POD 7, the total path length of the Lt.-UL group was significantly less than that of the Rt.-UL group (C). The percentage of time spent in the outer zone, which is an indicator of anxiety, did not differ between the three groups (D). Values are indicated as mean ± SD. Statistical significances were calculated using one-way ANOVA with post-hoc tests. *Significantly different between two groups; #significantly different between three groups; *, #p < 0.05; **p < 0.01; ***, ###p < 0.001.