Table 3.
Shikonin induces autophagy and inhibit cell proliferation
| Cancer types | Cell types | Molecular mechanism | References |
|---|---|---|---|
| Pncreatic cancer | BXPC-3, A375 | Asociated with the PI3K/Akt signaling pathway, p38 pathways | [74, 99] |
| Hpatocellular carcinoma | BEL7402 and Huh7 | Ativation of ERK | [100] |
| Colon cancer | HCT116 and SW620 | Inhibiting es-associated protein, targeting galectin-1/JNK signaling axis | [15, 101] |
| Non-small cell lung cancer | A549 | Regulated necroptosis | [75] |
| Skin Carcinogenesis | JB6 Cl-41 | Suppressed the ATF2,and Cdk4, | [76] |
| Esophageal cancer | EC109 and EC9706 | Decreased EGFR, PI3K, p-AKT, HIF1α and PKM2 | [78] |
| Esophageal cancer | KYSE150 | inhibited cell proliferation by suppressing PKM2 | [102] |
| Lung cancer | A549 and H446, | downregulating PFKFB2 expression | [103] |