TABLE 4.
Univariate and Multivariate Analysis for entire patients.
| Factors | Univariate analysis | Multivariate analysis | p value |
|---|---|---|---|
| p value | HR (95%CI) | ||
| Analysis of OS | |||
| Gender | 0.422 | ||
| Age (year) | |||
| <60 | References | References | |
| 60–70 | 0.912 | 0.913 (0.202–4.127) | 0.906 |
| >70 | 0.001 | 8.442 (2.562–27.815) | 0.001 |
| Tumor size (cm) | 0.401 | ||
| Smoking history | 0.066 | 1.673 (0.585–4.788) | 0.337 |
| 8th TNM stage | |||
| IA1 | References | ||
| IA2 | 0.944 | ||
| IA3 | 0.946 | ||
| Differentiation degree | 0.006 | 2.063 (0.837–5.087) | 0.116 |
| Vascular invasion | 0.513 | ||
| High-risk subtype | 0.002 | 3.624 (1.263–10.397) | 0.017 |
| Operative approach | 0.299 | ||
| EGFR gene mutation | |||
| Negative | References | ||
| Positive | 0.481 | ||
| Unknown | 0.415 | ||
| ALK rearrangement | |||
| Negative | References | ||
| Positive | 0.983 | ||
| Unknown | 0.784 | ||
| Number of N2 stations examined | 0.273 | ||
| Number of N1 stations examined | 0.219 | ||
| GGO component (positive VS. negative) | 0.010 | 3.186 (1.155–8.792) | 0.025 |
| Thoracotomy or VATS | 0.241 | ||
| Analysis of DFS | |||
| Gender | 0.203 | ||
| Age (year) | |||
| <60 | References | References | |
| 60–70 | 0.567 | 0.789 (0.401–1.550) | 0.491 |
| >70 | 0.080 | 1.553 (0.717–3.363) | 0.265 |
| Tumor size (cm) | 0.080 | 1.590 (0.969–2.611) | 0.067 |
| Smoking history | 0.172 | ||
| 8th TNM stage | |||
| IA1 | References | ||
| IA2 | 0.446 | ||
| IA3 | 0.179 | ||
| Differentiation degree | 0.005 | 1.455 (0.825–2.533) | 0.198 |
| Vascular invasion | 0.506 | ||
| High-risk subtype | 0.001 | 2.824 (1.448–5.509) | 0.002 |
| Operative approach | 0.297 | ||
| EGFR gene mutation | |||
| Negative | References | ||
| Positive | 0.584 | ||
| Unknown | 0.179 | ||
| ALK rearrangement | |||
| Negative | References | ||
| Positive | 0.945 | ||
| Unknown | 0.554 | ||
| Number of N2 stations examined | 0.892 | ||
| Number of N1 stations examined | 0.025 | 0.735 (0.573–0.944) | 0.016 |
| GGO component (positive vs. negative) | 0.003 | 1.877 (1.013–3.476) | 0.045 |
| Thoracotomy or VATS | 0.760 | ||
OS, overall survival; DFS, disease-free survival; VATS, video-assisted thoracoscopic surgery; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma kinase; GGO, ground-glass opacity.