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. 2001 May;21(9):2991–3000. doi: 10.1128/MCB.21.9.2991-3000.2001

FIG. 12.

FIG. 12

Dual regulation of SREBP-1c promoter by LXR-RXR and SREBPs. In the presence of excess amount of sterols, presumably a concomitant increase in oxysterol levels activates the SREBP-1c promoter through the LXRE complex while the cleavage activity of SREBPs is suppressed (A). When cells are deprived of sterols, increased nuclear SREBPs activate the SREBP-1c promoter through the SRE complex (B). The dual activation of the SREBP-1c promoter through LXRE and SRE complexes ensures the maintenance of lipogenesis irrespective of cellular sterol levels.