FIG. 4.

Activation of SREBP-1c promoter by LXR via the oxysterol-inducible region in the promoter. The previously identified oxysterol-inducible region and the SRE complex in the SREBP-1c promoter are illustrated at the top. pBP-1c2600-Luc and two shorter versions, pBP1c550- and pBP1c90-Luc, were prepared and used for transfection into 293 cells as described in Materials and Methods. Luciferase activity was measured and normalized to β-galactosidase activity. Fold induction of luciferase activity (mean ± standard deviation) by LXRs is shown.