Table 1.

Time effect (number of new consumers per week) before and during COVID-19 pandemic period according to age group and drug considered

		Anxiolytics				Hypnotics and sedatives				Antidepressants
		Coef.	95% CI		p	Coef.	95% CI		p	Coef.	95% CI		p
12–18 y	Number of new consumers per week before COVID-19 outbreak	−0.9	−2.53	0.73	0.279	−0.49	−0.65	−0.32	<10−4	6.03	5.07	6.99	<10−4
	Number of new consumers per week during COVID-19 outbreak	35.72	22.28	49.15	<10−4	18.46	17.08	19.85	<10−4	34.48	26.59	42.38	<10−4
	Number of consumers on 1 January 2015	6226	5960	6493	<10−4	743	715	770	<10−4	3570	3413	3727	<10−4
19–25 y	Number of new consumers per week before COVID-19 outbreak	1.71	−0.67	4.1	0.159	−5.87	−6.45	−5.28	<10−4	14.98	13.01	16.95	<10−4
	Number of new consumers per week during COVID-19 outbreak	55.92	36.31	75.54	<10−4	15.08	10.27	19.9	<10−4	87.12	70.91	103.33	<10−4
	Number of consumers on 1 January 2015	17 034	16 644	17 423	<10−4	4538	4443	4634	<10−4	12 446	12 124	12 768	<10−4
26–50 y	Number of new consumers per week before COVID-19 outbreak	−102.14	−133.43	−70.85	<10−4	−116.5	−128.02	−104.98	<10−4	−52.56	−82.79	−22.33	0.001
	Number of new consumers per week during COVID-19 outbreak	214.52	−42.7	471.75	0.102	123.77	29.09	218.45	0.011	247.11	−1.38	495.61	0.051
	Number of consumers on 1 January 2015	210 570	205 460	215 679	<10−4	85 355	83 475	87 236	<10−4	206 572	201 636	211 508	<10−4
51–75 y	Number of new consumers per week before COVID-19 outbreak	−43.93	−85.49	−2.37	0.038	−174.34	−195.5	−153.18	<10−4	100.85	60.41	141.29	<10−4
	Number of new consumers per week during COVID-19 outbreak	520	178.36	861.64	0.003	160.33	−13.58	334.25	0.071	486.18	153.72	818.63	0.004
	Number of consumers on 1 January 2015	366 345	359 558	373 132	<10−4	191 529	188 075	194 984	<10−4	345 589	338 985	352 194	<10−4
>75 y	Number of new consumers per week before COVID-19 outbreak	−50.15	−69.47	−30.83	<10−4	−125.52	−136.93	−114.11	<10−4	49.56	32.05	67.07	<10−4
	Number of new consumers per week during COVID-19 outbreak	189.71	30.88	348.53	0.019	40.72	−53.06	134.5	0.394	100.9	−43.06	244.86	0.169
	Number of consumers on 1 January 2015	213 733	210 578	216 888	<10−4	121 007	119 144	122 870	<10−4	190 597	187 737	193 456	<10−4

The number of new consumers per week before COVID-19 outbreak corresponds to the time effect of the linear model. The number of new consumers per week during COVID-19 outbreak corresponds to the linear combination between time effect and interaction between time effect and COVID-19 period. Finally, the number of consumers on 1 January 2015 corresponds to the intercept.