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. 2021 Dec 8;9:792111. doi: 10.3389/fbioe.2021.792111

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Copyright © 2021 Wei, Wang, Xiang, Jiang, Gong, Su, Al Azad, Dong, Feng, Wu, Chan, Yang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of vNAR immune repertoire of bamboo sharks during immunization. (A) Schematic for the characterization of vNAR immune repertoire constructed from immunized sharks. (B, C) Usage frequency of V/J genes from four IgNAR clusters. Statistical significance is indicated by the p value. (D, E) Variability of amino acid sequences (D) and CDR3 lengths (E) of vNARs (n = 3,00,000). CDR, complementarity determining region; HV, hypervariable region. (F, I) Clonotype overlap and clonotype tracking of vNAR immune repertoire of bamboo sharks during immunization. Peak positions represent the abundance profiles of top 100 clonotypes (colored), non-overlapping clonotypes (dark gray), and remaining (Not shown) clonotypes (light gray). Value in each tile of heatmap represents the clonotype overlap rate between two time points as shown on the two axes.