Table 1.
Biomarkers of OA and their BIPED classifications
| Biomarker | Biological fluid | BIPED classification78 | |
|---|---|---|---|
| Cartilage degradation | MMP | Serum | B79 P80 E81 B79 P80 E81 |
| CTX-II | Urine, synovial fluid | B82 P83 E81 D84 B82 P83 E81 D84 |
|
| Coll2-1 NO2 | Urine, serum | P85 P85 |
|
| C2C, C1, 2C | Urine, serum | P86 E87 P86 E87 |
|
| Cartilage synthesis | CS846 | Serum | E88 D89 E88 D89 |
| COMP | Serum | BP90 D89 BP90 D89 |
|
| YKL-40 | Serum, synovial fluid | B79 E91 B79 E91 |
|
| PIIANP | Serum | P92 P92 |
|
| PIICP | Serum, synovial fluid | P93 D94 P93 D94 |
|
| Bone degradation | NTX-I | Urine, serum | P95 D96 P95 D96 |
| CTX-I | Urine, serum | P95 P95 |
|
| D-PYR | Urine | B79 B79 |
|
| Bone synthesis | OC | Serum | P97 P97 |
| BSP | Serum | D98 D98 |
|
| Synovial degradation | Glc-Gal-PYR | Urine | D99 D99 |
| HA | Serum | B79 P100 B79 P100 |
|
| Synovial Synthesis | PIIINP | Serum | P101 D99 P101 D99 |
BIPED classification: Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic; BSP: bone sialoprotein; C2C, C1, 2C: collagenase-generated cleavage neoepitopes; Coll2-1 NO2: nitrated type II collagen degradation fragment; COMP: cartilage oligomeric matrix protein; CS846: chondroitin sulphate 846 epitopes; CTX-I: C-terminal telopeptide of collagen I; CTX-II: C-telopeptide of type II collagen fragment; D-PYR: deoxypyridinoline; Glc-Gal-PYR: glucosyl-galactosyl pyridinoline; HA: hyaluronic acid; MMP: matrix metalloproteinases; NTX-I: N-terminal telopeptide of collagen I; OC: osteocalcin; PIIANP: N-terminal propeptide of collagen IIA; PIICP: procollagen type II C-propeptide; PIIINP: type III procollagen; YKL-40: cartilage glycoprotein 39.