Table 1.
Spontaneous mammary tumor development in p18 and Gata3 mutant mice a
| Genotype | Tumor | ||
|---|---|---|---|
| Mammary tumor | Luminal Marker+ tumor d | Basal Marker+ tumor e | |
| WT | 0/9 | ||
| p18mt b | 8/27 (30%) | 6/8 (75%) | 2/8 (25%) |
| Gata3 +/- | 0/8 | ||
| p18mt;Gata3+/- c | 17/34 (50%)f | 3/17 (18%)g | 14/17 (82%)g, h |
a All mice were in Balb/c-B6 mixed background and were at 8-22 months of age.
b This group contains eight p18+/- and nineteen p18-/- mice.
c This group contains ten p18+/-;Gata3+/- and twenty four p18-/-;Gata3+/- mice.
d ER was detected in >2% tumor cells and Ck8 or E-Cad were detected in >50% tumor cells by IHC or IF.
e At least one of the basal markers (Ck5, Ck14, and Sma) was positively detected in >2% tumor cells by IHC or IF, as we previously reported (Bai, Oncogene, 2013; Cancer Res., 2014).
f No significance from p18mt;Gata3+/- and p18mt tumors by a two-tailed Fisher's exact test (p=0.124).
g Significance from p18mt;Gata3+/- and p18mt tumors by a two-tailed Fisher's exact test (p=0.010).
h Five mammary tumors metastasized to lung and/or liver.