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. 2022 Jan 1;12(2):910–928. doi: 10.7150/thno.66059

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LOX^high fibroblast (FB2) is predicted to play a critical role in the development of AD. (A) Monocle analysis showing the ordering of SMCs in pseudotime. Each dot indicates a cell. Each color indicates a cell state. Non-AD represents cells mainly from non-AD arteries; AD, from AD arteries; Transition, mixed cell source from both non-AD and AD. (B) Heatmap to display different blocks of top 1,000 differentially expressed genes (DEGs) along the pseudotime trajectory in (A). Selected top gene ontology (GO) terms related to corresponding DEGs are shown on the right. Functional analysis was performed with enrichGO in clusterProfiler, p < 0.05 was considered significant enrichment. (C) Heatmap to show the quantity of potentially matched pairs between ligands expressed by each cell cluster and SMC signaling pathways at different states (Non-AD, Transition, AD) in pseudotime. (D) Sum of all matched ligand-signaling pairs in (C).