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. 2022 Jan 1;12(2):910–928. doi: 10.7150/thno.66059

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Expression of dFB2 in human Non-AD and AD samples. (A) Expression levels of specific markers THY1 and PDPN in diseased FB2 (dFB2), as well as in other clusters based on scRNA-seq data. (B) Immunofluorescent staining of FB2 specific marker (LOX) and dFB2 specific markers THY1 or PDPN in human Non-AD or AD sections, respectively. White arrows indicate co-localization, yellow arrows indicate LOX⁺ only cells. Scale bars, 50 μm (left four columns); 25 μm (magnifications). M, media; A, adventitia. The representative images are from 3 and 4 independent experiments (3 samples each), respectively. (C, D) Quantitative analysis of THY1^highLOX⁺ (C) or PDPN^highLOX⁺ (D) cells in Non-AD versus AD arteries. n = 3 and 5 in Non-AD and AD group, respectively. ***p < 0.001 (Wilcoxon rank-sum test).