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. 2022 Jan 1;12(2):603–619. doi: 10.7150/thno.67410

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Doxorubicin treatment does not significantly alter mitochondrial function or morphology in neuronal synaptosomes. After completion of cognitive tests, synaptosomes were isolated from the brains of mice treated with doxorubicin or PBS. Oxygen consumption rates (OCR) were analyzed in isolated synaptosomes using the Seahorse XFe24 Flux Analyzer. (A) Basal respiration, (B) spare respiratory capacity, and (C) maximum respiratory capacity results are shown. (D) Mitochondrial morphology in synaptosomes was assessed using transmission electron microscopy. Arrows indicate mitochondria. (E) Percentage of atypical mitochondria was quantified. OCR results are expressed as mean ± SEM; n = 9 mice/group; Unpaired t test. Mitochondrial morphology results are expressed as mean ± SEM; n = 4 mice (26-34 mitochondria)/group; Unpaired t test.