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. 2022 Jan 1;12(2):767–781. doi: 10.7150/thno.65948

Figure 7.

Figure 7

Podocyte-specific ablation of CXCR4 inhibits β-catenin signaling in ADR model. (A) Representative micrographs show the immunohistochemical staining of glomerular β-catenin, active β-catenin and MMP-7 in WT and KO mice at 2 weeks after ADR. Arrows indicate positive staining. Scale bar, 20 µm. (B-F) Western blot analyses show that podocyte-specific ablation of CXCR4 reduced renal expression of β-catenin, active β-catenin, MMP-7 and Snail1 proteins at 2 weeks after ADR. Representative Western blot (B) and quantitative data of β-catenin (C), active β-catenin (D), MMP-7 (E) and Snail1 (F) proteins in different groups as indicated. Numbers (1-4) indicate each individual animal in a given group. *P < 0.05 versus +/+ (n = 5).