Figure 1.

Trained immunity prevents mice against sepsis in vivo. (A) Schematic of sepsis after trained immunity experimental setup (n = 5). (B) Blood (upper) and peritoneal lavage fluid (below) from mice 24 h after infection was plated for 16 h. Representative plate shows bacterial colonies. Representative H&E staining of (C) lung sections or (E) liver sections. Scale bars, 100 µm. Histological injury of (D) lungs and (F) livers in different groups scored as described in Materials and Methods. Data are shown as mean ± SEM (n = 5). *P < 0.05; **P < 0.01.