Table 3.
Antioxidant nanoparticles targeting mitochondrial oxidative stress in ischemic stroke.
| S. No. | Therapeutic Loading Molecule | Nanocarriers Used | Mode of Action | References |
|---|---|---|---|---|
| 1. | Cerium Oxide/ Ceria | Polyethylene glycol; TPP | Mimic SOD Activity; Anti-inflammatory effects | 89, 94, 17, 97, 98 |
| 2. | Silica | Silica NPs | ||
| 3. | Iron Oxide | Iron oxide NPs | ||
| 4. | Platinum | PtNPs | ||
| 5. | Selenium | Selenium NPs | ||
| 6. | Free Radical Scavengers | Polyanhydrides; Chitosan; TPP; Polyethylene glycol | Scavenging ROS; Inhibiting Oxidative Stress Damage | 89 |
| 7. | Gallic Acid | Chitosan | Reduce Oxidative Stress | 99 |
| 8. | Resveratrol | Solid-Lipid Nanoparticles; Polymer nanoparticles | Enhance mitochondrial function; Reduce LDH and MDA content release | 100 |
| 9. | Curcumin | DQAsomes; PLGA-PEG; Solid-Lipid nanoparticles | Antioxidant effect | 90, 101, 102 |
| 10. | Quercetin | PLGA | Scavenging ROS; Inhibiting Oxidative Stress Damage | 103, 104 |
| 11. | TNF-α | Polyethylene glycol | Attenuate oxidative stress and inflammatory response post IS injury | 108 |
| 12. | Activated SOD enzyme | PLGA; Liposomes | ROS scavenging; Anti-inflammatory response | 109 |