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. 2022 Jan 1;12(2):929–943. doi: 10.7150/thno.66148

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Suppression of the growth of mammary tumors and the protection of tumor-invaded bone by Lrp5 CM. pl = placebo, CM = osteoblast-derived conditioned medium, and Lrp5 = Lrp5 overexpression. The double asterisk indicates p < 0.01. (A-B) Reduction in the size and weight of mammary tumors by the daily administration of Lrp5 CM, N = 10. (C) Prevention of bone loss in the tumor-invaded tibia by Lrp5 CM. BV/TV = bone volume ratio, BMD = bone mineral density, Tb.N = trabecular number, and Tb.Sp = trabecular separation, N = 10. (D) Reduction in the tumor-invaded area (green-outlined region) by the daily administration of Lrp5 CM, N = 10.