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. 2022 Jan 1;12(2):929–943. doi: 10.7150/thno.66148

Figure 3.

Figure 3

Reduction in tumor invasion to the lung, shrinkage of ex vivo cancer tissue fragments, and elevation of apoptosis-linked proteins in EO771 cells by CM. pl = placebo, Lrp5 = Lrp5 overexpression, CM = osteoblast-derived conditioned medium, and EO = EO771. The single and double asterisks indicate p < 0.05 and 0.01, respectively. (A) Reduction in the invasion of EO771 mammary tumor cells into the lung by Lrp5 CM, N = 6. (B) Reduction in Runx2 and Snail in the lung by Lrp5 CM. (C-D) Shrinkage of ex vivo breast and prostate cancer tissue fragments by Lrp5 CM and BML284-treated CM, N = 8. (E) Enrichment of the apoptosis-linked proteins such as Bad, Bcl-2, Bcl-x, Claspin, CD95, and HSPA1A in EO771 breast tumor cells by Lrp5 CM. (F) Elevation of CD95 in EO771 breast tumor cells by Lrp5 CM.