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. 2022 Jan 1;12(2):929–943. doi: 10.7150/thno.66148

Figure 5.

Figure 5

Dichotomous role of osteopontin in osteoblasts and EO771 mammary tumor cells. Lrp5 = Lrp5 overexpression, OPN = osteopontin overexpression, Ob = osteoblasts, EO = EO771, and CM = osteoblast-derived conditioned medium. The single and double asterisks indicate p < 0.05 and 0.01, respectively. (A) Osteopontin elevation and TGFβ reduction in Lrp5-overexpressing osteoblasts. The reduction in osteopontin and TGFβ in Lrp5 CM, and Lrp5 CM-treated EO771 mammary tumor cells. (B-D) Reduction in the scratch-based motility, EdU-based proliferation, and transwell invasion of EO771 mammary tumor cells by OPN-overexpressing CM. (E-F) Stimulation of the EdU-based proliferation and transwell invasion in EO771 cells by the overexpression of OPN.