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(A) T1 relaxation measures the time it takes the initial longitudinal magnetic moment (M0) to restore. T2 relaxation is a measurement of the reduction of the transverse magnetic moment (Mxy). (B) A summary of the advantages and disadvantages of first, second and the probable subsequent generations of MRI contrast agents. MIONs: magnetic iron oxide nanoparticles; ES-MIONs: extremely small MIONs. Reproduced with permission from references 43, 48.
