Table 3.

Examples of ferumoxytol in diagnostic, therapeutic, and theranostic applications.

Type of applications	Applications	Indications	Route	Ref.
Diagnosis	HPF was used to label neural stem cells for MRI	Glioma	i.v. injection	71, 73
	Segregation and extravascular localization of ferumoxytol imaging for differentiating extravascular-from-intravascular MRI	Globlastoma	i.v. injection	85
	Ferumoxytol for MR lymphography	Prostate Cancer	i.v. injection	94, 95
	Ferumoxytol-enhanced MRI for vascular applications	Evaluating vascular pathology, presurgical planning	i.v. injection	101
	Multi-modal imaging integrating MRI and PET	Pediatric Cancer	i.v. injection	112, 113
Therapy	Iron supplement for anemic patients	Chronic kidney disease	i.v. injection	19, 20
	Ferumoxytol induced selective cell death in cells that express low levels of ferroportin	Leukaemia	i.p. injection	149
	Ferumoxytol changes the polarization of tumor-associated macrophages to a pro-inflammatory M1 phenotype	MMTV-PyMT cancer, melanoma	i.v. injection	140, 143
	Bacterial pathogen killing and biofilm disruption	Dental caries	Topical oral delivery	13
Theranostics	Ferumoxytol acted as nanovehicle to load drug and monitor drug release using MRI	Prostate cancer, breast cancer	i.v. injection	29