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. 2022 Jan 1;12(2):963–975. doi: 10.7150/thno.65411

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Intestinal epithelial-specific KI of Hmga2 promoted TAM infiltration, M2 polarization, and CCL2 secretion in the AOM/DSS model. A, Schematic overview of AOM/DSS mouse model in WT and Hmga2 KI mice. B, Representative images (left panel) and the total number (right panel) of intestinal tumors induced by AOM/DSS. C, Representative flow cytometry plots (left panel) and percentages (right panel) of CD11b⁺F4/80⁺ macrophages (upper panel) and CD11b⁺F4/80⁺CD206⁺ M2 macrophages (bottom panel) in intestinal tissues. D, Quantitative RT-PCR analysis of CCL2, TNF-α, and TGF-β in intestinal tissues. E, ELISA analysis of the concentrations of CCL2, TNF-α, and TGF-β in the cultured supernatants from intestinal tissues. Error bars indicate SD. *P < 0.05; **P < 0.01; ***P < 0.001.