Schematic representation of current and future monitoring of glycemic control in type 1, type 2 and gestational diabetes. In green, blood is used for the detection of glucose and other markers of glycemic control. In orange, non-invasive biological fluids for glucose detection. Currently, the only approved FDA non-invasive methods for glucose detection employ ISF. Multiplex invasive or non-invasive assays may be foreseen in the future to integrate glucose measurement in the follow-up of patients with diabetes, elderly type 2 diabetes, and prediabetes, as well as to support diabetes related research.