Table 2.

Classification of enzymatic glucose sensors

Classification	Characteristics
1st Generation	Based on the sensor designed by Clark and Lyons Formation of hydrogen peroxide Oxygen as an electron acceptor Errors due to interference from other electroactive species
2nd Generation	Replacement of oxygen as an electron acceptor Introduction of the non-physiological mediator Limitations in the transfer from the enzymatic active site to the electrode
3rd Generation	Absence of mediator Direct transfer between enzyme and electrode Low operating potential, higher selectivity, less interference