TABLE 2.
Group differences in subcortical volume.
| Brain structure (mm3) | Early menopausal women | Premenopausal controls | p-value |
| Left lateral ventricle | 6252.21 ± 3503.31 | 5520.95 ± 2401.37 | 0.223(N.S.) |
| Left inf lateral ventricle | 163.66 ± 110.36 | 153.91 ± 129.07 | 0.691(N.S.) |
| Left cerebellum WM | 15288.99 ± 3624.12 | 16296.78 ± 3154.71 | 0.142(N.S.) |
| Left cerebellum cortex | 44147.05 ± 3594.56 | 44710.40 ± 4449.10 | 0.496(N.S.) |
| Left thalamus proper | 7463.40 ± 884.33 | 7564.60 ± 752.37 | 0.540(N.S.) |
| Left caudate | 3223.36 ± 360.89 | 3267.29 ± 423.03 | 0.584(N.S.) |
| Left putamen | 4774.27 ± 619.40 | 4921.89 ± 654.90 | 0.255(N.S.) |
| Left pallidum | 1166.98 ± 192.86 | 1159.55 ± 244.04 | 0.869(N.S.) |
| 3rd Ventricle | 899.43 ± 239.45 | 866.91 ± 213.48 | 0.477(N.S.) |
| 4th Ventricle | 1506.30 ± 327.59 | 1578.42 ± 410.91 | 0.344(N.S.) |
| Brainstem | 18776.61 ± 1463.83 | 18770.68 ± 1786.76 | 0.986(N.S.) |
| Left hippocampus | 4264.5 ± 378.73 | 4388.35 ± 325.86 | 0.083(N.S.) |
| Left amygdala | 1456.82 ± 161.14 | 1659.83 ± 184.13 | 0.000 |
| CSF | 1064.46 ± 171.35 | 1053.93 ± 186.33 | 0.772(N.S.) |
| Left accumbens area | 506.14 ± 86.70 | 509.22 ± 87.17 | 0.861(N.S.) |
| Left ventral DC | 3918.08 ± 429.21 | 4005.81 ± 498.07 | 0.355(N.S.) |
| Left vessel | 76.63 ± 27.61 | 87.97 ± 34.66 | 0.079(N.S.) |
| Left choroid plexus | 1046.57 ± 251.98 | 1071.09 ± 188.52 | 0.581(N.S.) |
| Right lateral ventricle | 5294.26 ± 2777.51 | 5089.72 ± 2360.91 | 0.693(N.S.) |
| Right inf lateral ventricle | 176.00 ± 135.55 | 134.56 ± 88.30 | 0.070(N.S.) |
| Right cerebellum WM | 16407.57 ± 4514.47 | 16265.99 ± 4161.08 | 0.871(N.S.) |
| Right cerebellum cortex | 45685.92 ± 4384.58 | 45987.90 ± 4765.02 | 0.746(N.S.) |
| Right thalamus proper | 6581.79 ± 535.33 | 6735.46 ± 564.35 | 0.171(N.S.) |
| Right caudate | 3248.55 ± 334.75 | 3219.34 ± 344.27 | 0.671(N.S.) |
| Right putamen | 4443.09 ± 527.18 | 4600.41 ± 541.89 | 0.149(N.S.) |
| Right pallidum | 1184.70 ± 239.19 | 1204.79 ± 209.65 | 0.657(N.S.) |
| Right hippocampus | 4317.52 ± 283.55 | 4449.22 ± 349.49 | 0.051(N.S.) |
| Right amygdala | 1556.95 ± 135.78 | 1671.55 ± 182.06 | 0.001 |
| Right accumbens area | 471.36 ± 78.36 | 495.97 ± 80.29 | 0.128(N.S.) |
| Right ventral DC | 4054.47 ± 461.67 | 4142.84 ± 485.22 | 0.359(N.S.) |
| Right vessel | 83.15 ± 31.99 | 88.62 ± 47.44 | 0.512(N.S.) |
| Right choroid plexus | 1135.38 ± 357.74 | 1198.40 ± 220.87 | 0.286(N.S.) |
| Optic chiasm | 288.21 ± 59.41 | 295.87 ± 57.85 | 0.518(N.S.) |
| CC_posterior | 906.81 ± 153.71 | 915.53 ± 114.45 | 0.747(N.S.) |
| CC_mid-posterior | 431.92 ± 98.07 | 435.34 ± 104.08 | 0.868(N.S.) |
| CC_central | 502.99 ± 138.19 | 517.19 ± 120.47 | 0.586(N.S.) |
| CC_mid-anterior | 459.74 ± 118.25 | 469.97 ± 97.08 | 0.637(N.S.) |
| CC_anterior | 746.52 ± 120.49 | 787.42 ± 116.37 | 0.090(N.S.) |
| lhSurfaceHoles | 60.77 ± 17.26 | 58.90 ± 12.54 | 0.535(N.S.) |
| rhSurfaceHoles | 62.24 ± 12.29 | 64.75 ± 17.18 | 0.413(N.S.) |
| SurfaceHoles | 123.02 ± 27.31 | 123.66 ± 26.50 | 0.906(N.S.) |
CSF, cerebrospinal fluid; WM, white matter; inf, inferior; lat, lateral; DC, dorsal cortex; CC, cerebral cortex; lh, left hemisphere; rh, right hemisphere; N.S., not significant.