Table 2.
Selected genes involved in Tfh cell biology
| Transcription factors |
Functionality |
Regulation | Positioning | Activation | Signaling | |||
|---|---|---|---|---|---|---|---|---|
| Tfh phenotype enhancers | Tfh phenotype repressors | Others | Cytokines/Chemokines | Co-stimulation | ||||
| BCL6 | PRDM1 | FoxP3 | IL21 | ICOS | IL1R1 | CCR5 | IL7R | STAT1 |
| BATF | FOXO1 | TBX21 | CXCL13 | CD28 | IL2RA | CXCR4 | MKI67 | STAT3 |
| IRF4 | KLF2 | RORC | IFNG | CD40LG | BTLA | CCR6 | CD38 | STAT4 |
| MAF | PRKD2 | GATA3 | TNF | CTLA4 | PDCD1 | CCR7 | CD44 | STAT5A |
| ZBTB7B (Thpok) | BACH2 | IL2 | SH2D1A (SAP) | IL1R2 | CXCR3 | CD69 | ||
| TOX2 | ID2 | IL10 | TNFRSF4 (Ox40) | IL6R | CXCR5 | |||
| ASB2 | IL13 | CD27 | FAS | SELL (CD62L) | ||||
| TCF3 (E2A) | IL4 | SLAMF1 | S1PR1 | |||||
| TCF7 (TCF-1) | TNFRSF18 (GITR) | |||||||
| LEF1 | ||||||||
Based on the literature, we reviewed several molecules whose seminal role in Tfh cell development and function was shown.