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. 2021 Dec 21;9(12):e003439. doi: 10.1136/jitc-2021-003439

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Determination of functional TAA-reactive T cell profiles in the peripheral blood of patients with stage IV melanoma under PD-1 blockade. (A) Study design and experimental workflow. (B) Distribution of NY-ESO-1-reactive and Melan-A-reactive (dark blue), NY-ESO-1-reactive (blue) or Melan-A-reactive (light blue) T cell populations or the absence (purple) of both populations before the start of PD-1 blockade in both cohorts. (C) Proportions of circulating NY-ESO-1-reactive/Melan-A-reactive T cell populations under PD-1 blockade in either cohort. Green highlight indicates patients with a loss of at least one TAA-reactive T cell population under therapy. BL, baseline; FU, follow-up; IFN-γ, interferon gamma; PD-1, programmed cell death protein 1; TAA, tumor-associated antigen.