Table 3.
Comparison of baseline/outcome parameters at threshold value of HOMA-IR
SI. No. | Parameters | HOMA-IR <1.61 (n = 66) | HOMA-IR ≥ 1.61 (n = 16) | p value | |
---|---|---|---|---|---|
1. | Age (years) | 39.45 ± 14.43 | 38.50 ± 14.91 | 0.819 | |
2. | Sex (males) | 37 (56.0%) | 9 (56.2%) | 0.836 | |
3. | Weight (kg) | 57.76 ± 12.14 | 62.81 ± 13.84 | 0.194 | |
4. | APACHE II | 17.79 ± 6.39 | 18.25 ± 5.58 | 0.792 | |
5. | SOFA score | 8.3 ± 3.06 | 8.75 ± 2.95 | 0.595 | |
6. | FIL (mU/L) | 2.17 ± 1.36 | 7.42 ± 4.16 | <0.001 | |
7. | FBG (mg/dL) | 134.33 ± 50.60 | 160.25 ± 53.29 | 0.092 | |
8. | HbA1c (%) | 5.235.23 ± 0.47 | 5.295.23 ± 0.33 | 0.579 | |
9. | No. of organ involvement | 3.33 ± 1.12 | 3.38 ± 1.02 | 0.887 | |
10. | Type of organ involvement | Respiratory | 49 (74.2%) | 9 (56.2%) | 0.156 |
Hepatic | 25 (37.8%) | 6 (37.5%) | 0.978 | ||
Nervous | 35 (53%) | 8 (50%) | 0.828 | ||
Hematological | 26 (39%) | 7 (43%) | 0.750 | ||
Hemodynamic | 48 (72%) | 12 (75%) | 0.854 | ||
Renal | 27 (60%) | 12 (75%) | 0.239 | ||
11. | Noradrenaline requirement (mL) | 223.13 ± 245.09 | 387.81 ± 328.13 | 0.075 | |
12. | Vasopressin requirement (mL) | 22.66 ± 33.47 | 41.36 ± 44.103 | 0.128 | |
13. | Mechanical ventilation days | 9.56 ± 9.84 | 9.19 ± 8.53 | 0.880 | |
14. | ICU length of stay (days) | 11.98 ± 11.53 | 9.94 ± 9.27 | 0.458 | |
15. | Hospital length of stay (days) | 19.39 ± 16.50 | 12.31 ± 10.40 | 0.039 | |
16. | 28-day mortality | 24 (36.4%) | 14 (87.5%) | <0.001 |
Data presented as mean ± standard deviation, number (percentage). APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; FIL, fasting insulin levels; FBG, fasting blood glucose; HOMA-IR, homeostatic model assessment of insulin resistance. Noradrenaline: 1 mL = 0.08 mg; Vasopressin: 1 mL = 1 unit. A p <0.05 is considered significant