Table 2.
Accuracy of serum carcinoembryonic antigen and carbohydrate antigen 19–9 as diagnostic biomarkers of cancer based on cut-off levels
| Biomarker | Cut-off (μg/l) | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
| CEA | 5 | 0.541 | 9.0 | 99.2 | 78.5 | 77.5 | 78.6 |
| 2.3 | 0.606 | 35.5 | 85.7 | 74.2 | 42.4 | 81.7 | |
| CA19–9 | 37 | 0.753 | 56.2 | 94.5 | 85.7 | 75.2 | 87.9 |
| 25.6 | 0.777 | 66.5 | 88.9 | 83.8 | 64.1 | 89.9 |
AUC, area under the curve; CA19–9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; NPV, negative predictive value; PPV, positive predictive value.