Table 3.
Univariable and multivariable linear regression analyses of the associations between IL-6 measured at day 1 and final infarct size assessed by cardiac MRI at 4 months
| Variable | β | 95% CI | P value |
| Univariable | |||
| IL-6 (ln), per SD | 4.7 | 3.3 to 6.1 | <0.001 |
| Age | 0.01 | −0.1 to 0.1 | 0.93 |
| Male sex | 3.8 | 0 to 7.6 | 0.05 |
| Time from symptom to PCI (per hour) | 1.0 | 0.04 to 2.0 | 0.04 |
| Anterior MIa | 10.2 | 7.5 to 12.9 | <0.001 |
| Peak troponin T (ln), per SD | 9.1 | 8.1 to 10.0 | <0.001 |
| Multivariable model 1 | |||
| IL-6 (ln), per SD | 3.7 | 2.4 to 5.0 | <0.001 |
| Time from symptom to PCI (per hour) | 0.9 | 0.06 to 1.8 | 0.04 |
| Anterior MI | 9.1 | 6.5 to 11.7 | <0.001 |
| Multivariable model 2 | |||
| IL-6 (ln), per SD | 1.5 | 0.6, 2.6 | 0.002 |
| Anterior MI | 4.4 | 2.4, 6.4 | <0.001 |
| Peak troponin T (ln), per SD | 7.8 | 6.7, 8.8 | <0.001 |
Model 1: IL-6, age, gender, time from symptom to PCI, anterior MI. Model 2: model 1+peak troponin T. aInfarct localisation—anterior myocardial infarction (MI) versus inferior or posterior MI.
IL, interleukin; ln, natural logarithm; PCI, percutaneous coronary intervention; β, unstandardised β.