Table 2.

Evaluation and approval of the application by the National ALS Registry review committee.

Evaluation	Criteria
1. Scientific merit (A-D is considered acceptable)	A. Outstanding/B. Excellent/C. Good/D. Acceptable/E. Unacceptable
2. Will the proposal provide useful information for ALSa patients? (A-C is considered acceptable)	A. High potential/B. Strong potential/C. Good potential/D. Limited potential/E. No apparent potential
3. Are the patient contact procedures and materials clear?	Yes/No/Requires more information
4. Are the patient contact procedures and materials appropriate, necessary, and sufficient?	Yes/No/Requires more information
5. In your judgment, would most ALS patients find the demands of the protocol reasonable?	Yes/No/Requires more information
6. Is there an acceptable risk/benefit ratio?	Yes/No/Requires more information
7. Are there adequate protections for patient confidentiality and privacy?	Yes/No/Requires more information
8. Does the proposal reach a satisfactory threshold for all 7 criteria listed above?	Yes/No
9. Do you support approval of the proposal as it has been submitted?	Yes/No
Comments for the investigators (limit of 500 words)

^aALS: amyotrophic lateral sclerosis.