Skip to main content
. 2021 Dec 21;326(23):2385–2394. doi: 10.1001/jama.2021.21187

Figure 1. Flow of Participants in the Vitamin D and Omega-3 Trial (VITAL)–Depression Endpoint Prevention Ancillary Study to the VITAL Triala.

Figure 1.

aThe participant flow diagram for the 25 871 participants randomized in VITAL has been provided elsewhere.15

bIncluded 76 190 individuals with history of cardiovascular disease, cancer, and/or safety exclusion criteria; 32 647 individuals unwilling to forgo supplemental vitamin D3 intake greater than 800 IU/d, supplemental calcium intake greater than 1200 mg/d, or fish oil supplementation during the trial; 13 521 men younger than 50 years and women younger than 55 years; and 4465 individuals who reported another exclusion criterion (eg, participation in another trial).

cParticipants could have had more than 1 exclusion condition. ICD indicates, International Classification of Diseases; OCD, obsessive-compulsive disorder; PHQ-8, 8-item Patient Health Questionnaire; PTSD, posttraumatic stress disorder.