Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Treatment-Related Serious Adverse Events Observed
| Toxicity Observed | Timing of Event | Dose Level | Comments |
|---|---|---|---|
| Left ventricular ejection fraction decrease | C2D1 | 1 | Asymptomatic, LV thrombus identified |
| Atrial fibrillation | C2D8 | 1 | Clinical heart failure |
| Pulmonary embolus | C1D12 | 1 | with hemoptysis, ICU stay |
| Myocardial infarction | C1D19 | 2 | ST elevation myocardial infarction |
| Gastrointestinal bleed | C4D8 | 2 | Grade 5 (required before dose reduction) |
ICU, intensive care unit; LV, left ventricle.
