Fig. 6. Free energy landscapes constructed by using projections of the single joined MSMD trajectories corresponding to the first two principal components PC1 and PC2 from the diagonalization of covariance matrix: (A) the 8NS-BD1 complex, (B) the 8NS-BD2 complex, (C) the 82Y-BD1 complex, (D) the 82Y-BD2 complex, (E) the 837-BD1 complex and (F) the 837-BD2 complex.