TABLE 2.
Phylogenetically inferred root date estimates and within-host evolutionary rates
|
Participant |
ΔAICa | Clinically estimated infection date | Phylogenetically estimated root date (95% CI) | Within-host HIV evolutionary rateb |
|---|---|---|---|---|
| 1 | 21.1 | Apr 2006 | Feb 2007 (Dec 2004 to Apr 2009) | 3.22 × 10−5 |
| 2 | 37.8 | Dec 2005 | Jan 2003 (Feb 1999 to Dec 2006) | 1.17 × 10−5 |
| 3 | 39.2 | Mar 2008 | Oct 2006 (May 2004 to Feb 2009) | 1.16 × 10−5 |
| 4 | 30.3 | Mar 2005 | June 2005 (Nov 2003 to Jan 2007) | 1.28 × 10−5 (control era) |
| 167.2 | 5.35 × 10−5 (post-control era) |
a
ΔAIC, delta Akaike information criterion. A ΔAIC of ≥10 was considered evidence of a molecular clock signal (see Materials and Methods).
b
Expressed in estimated substitutions per nucleotide site per day.