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. 2021 Dec 22;21:494. doi: 10.1186/s12883-021-02527-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Changes in biomarkers after initiation of antiretroviral therapy (ART) in individuals with HIV-associated dementia (HAD). (A) albumin ratio, (B) CSF neopterin, (C) CSF HIV RNA. Colors represent levels of albumin ratio at baseline by quantiles (red indicates the highest quantile, orange the second highest, yellow the third highest, green the fourth highest and blue the quantile with the lowest baseline levels). Horizontal black lines represent upper normal reference value, except (C), which shows limit of detection of viral copies/mL. (CSF β2-microglobulin, IgG index, and CSF NfL not analyzed due to lack of samples.) Scale of X-axis is square root of days since ART initiation